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PUBLICATIONS
Human Spectral Karyotyping (SKY™) K.K. Aben, M.V. Macville, D.F. Smeets, M.P. Schoenberg, J.A. Witjes, L.A. Kiemeney (2001) Absence of karyotype abnormalities in patients with familial urothelial cell carcinoma. Urology 57: 266-269. A. Adeyinka, S. Kytola, F. Mertens, N. Pandis, C. Larsson (2000) Spectral karyotyping and chromosome banding studies of primary breast carcinomas and their lymph node metastases. Int J Mol Med 5: 235-240. R.J. Allen, S.D. Smith, R.L. Moldwin, M.M. Lu, L. Giordano, C. Vignon, Y. Suto, A. Harden, R. Tomek, T. Veldman, T. Ried, R.A. Larson, M.M. Le Beau, J.D. Rowley, N. Zeleznik-Le (1998) Establishment and characterization of a megakaryoblast cell line with amplification of MLL. Leukemia 12: 1119-1127. H.G. Ahuja, L. Popplewell, L. Tcheurekdjian,
M.L. Slovak (2001) NUP98 gene rearrangements and
the clonal evolution of chronic myelogenous leukemia. Genes,
Chromosomes and Cancer30: 410-415. Y. Ariyama, Y. Fukuda, Y. Okuno, M. Seto, K. Date, T. Abe, Y. Nakamura, J. Inazawa (1998) Amplification on double-minute chromosomes and partial-tandem duplication of the MLL gene in leukemic cells of a patient with acute myelogenous leukemia. Genes Chromosomes Cancer 23: 267-72. Y. Ariyama, T. Sakabe, T. Shinomiya, T. Mori, Y. Fukuda, J. Inazawa. (1998) Identification of amplified DNA sequences on double minute chromosomes in a leukemic cell line KY821 by means of spectral karyotyping and comparative genomic hybridization. J. Hum. Genet. 43: 187-190. C. Astbury, C.K. Jackson-Cook, S.H. Culp, T.E. Paisley, J.L. Ware (2001) Suppression of tumorigenicity in the human prostate cancer cell line M12 via microcell-mediated restoration of chromosome 19. Genes, Chromosomes and Cancer 31: 143-155. M. Barnard, J. Bayani, R. Grant, I. Teshima, P., J. Squire (2000) Use of multicolor spectral karyotyping in genetic analysis of pleuropulmonary blastoma. Pediatr Dev Pathol. 3: 479-486. J. Bayani, M. Zielenska, P. Marrano, N.G. Kwan, M.D. Taylor, V. Jay, J.T. Rutka, J.A. Squire (2000) Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping. J Neurosurg. 93: 437-448. J. Bayani, A. Pandita, J.A. Squire (2000) Sequential G-banding, SKY and FISH provides a refined identification of translocation breakpoints and complex chromosomal rearrangements. Technical Tips Online 01864. B. Beheshti, P.C. Park, J.M. Sweet, J. Trachtenberg, M.A. Jewett, J.A. Squire JA (2001) Evidence of Chromosomal instability in prostate cancer determined by spectral karyotyping (SKY) and interphase FISH analysis. Neoplasia 3: 62-69. B. Beheshti, J. Karaskova, P.C. Park, J.A. Squire, B.G. Beatty (2000) Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer cell lines by sequential Giemsa-banding and spectral karyotyping. Molecular Diagnosis 5: 23-32. K.C. Bible, S.A. Boerner, K. Kirkland, K.L. Anderl, D. Bartelt Jr, P.A. Svingen, T.J. Kottke, Y.K. Lee, S. Eckdahl, P.G. Stalboerger, R.B. Jenkins, S.H. Kaufmann (2000) Characterization of an ovarian carcinoma cell line resistant to cisplatin and flavopiridol. Clinical Cancer Res. 6:661-670. G. Borck, J Wirth, T Hardt, H Tönnies, K Brøndum-Nielsen, M Bugge, N Tommerup, H-G Nothwang, H-H Ropers, And T Haaf (2001) Molecular cytogenetic characterisation of a complex 46,XY,t(7;8;11;13) chromosome rearrangement in a patient with Moebius syndrome. J Med Genet 38: 117-121. G. Calabrese, D. Fantasia, P.G. Franch, E. Morizio, L. Stuppia, V. Gatta, P. Olioso, R. Mingarelli, A. Spadano, G. Palka (2000) Spectral karyotyping (SKY) refinement of a complex karyotype with t(20;21) in a Ph-positive CML patient submitted to peripheral blood stem cell transplantation. Bone Marrow Transplant 26: 1125-1127. G. Calabrese, D. Fantasia, A. Spadano, M. Morizio, P. Di Bartolomeo, G. Palka (2000) Karyotype refinement in five patients with acute myeloid leukemia using spectral karyotyping. Haematologica 85: 1219-1221. C.G. Carlotti Jr, J.M. Drake, J. Hladky, I. Teshima, L.E. Becker, J.T. Rutka (1999) Primary Ewing's sarcoma of the skull in children. Utility of molecular diagnostics, surgery and adjuvant therapies. Pediatr Neurosurg. 31: 307-315. J.A. Caruso, J.J. Reiners, J. Emond, T. Shultz, M.A. Tainsky, M. Alaoui-Jamali, G. Batist (2001) Genetic alteration of chromosome 8 is a common feature of human mammary epithelial cell lines transformed in vitro with benzo[a]pyrene. Mutat Res. 473: 85-99. S.R. Chaganti, P.H. Rao, W. Chen, V. Dyomin, S.C. Jhanwar, N.Z. Parsa, R. Dalla-Favera, R.S.K. Chaganti (1998) Deregulation of BCL6 in non-Hodgkin lymphoma by insertion of IgH sequences in complex translocations involving band 3q27. Genes Chromosomes Cancer 23: 328-336. Chen Z, Coffin CM, Smith LM, Issa B, Arndt S, Shepard R, Brothman L, Stratton J, Brothman AR, Zhou H. (2001) Cytogenetic-clinicopathologic correlations in rhabdomyosarcoma: a report of five cases. Cancer Genet Cytogenet. 131: 31-36. Z. Chen, C.M. Coffin, S. Scott, A.
Meloni-Ehrig, R. Shepard, B. Issa, D.R. Forsyth, A.A. Sandberg,
A.R. Brothman, A. Lowichik A. (2000) Evidence by spectral karyotyping
that 8q11.2 is nonrandomly involved in lipoblastoma. Clarkson B, Pavenski K, Dupuis L, Kennedy
S, Meyn S, Nezarati MM, Nie G, Weksberg R, Withers S, Quercia
N, Teebi AS, Teshima I. (2002) Detecting rearrangements in children
using subtelomeric FISH and SKY. I.J. Cohen, J. Issakov, S. Avigad, B. Stark, I. Meller, R. Zaizov, I. Bar-Am (1997) Synovial sarcoma of bone delineated by spectral karyotyping. The Lancet 350:1679-1680. Stark, S. Avigad (2000) Letter to the editor: synovial sarcoma mimicking desmoplastic small round-cell tumor: critical role for molecular diagnosis. Med. Pediatr. Oncol. 34: 234. N. Cohen, D.R. Betts, L. Trakhtenbrot, F.K. Niggli, N. Amariglio, F. Brok-Simoni, G. Rechavi, D. Meitar (2001) Detection of unidentified chromosome abnormalities in human neuroblastoma by spectral karyotyping (SKY). Genes Chromosomes Cancer 31: 201-208. A. Cottage, S. Dowen, I. Roberts, M. Pett, N. Coleman, M. Stanley (2000) Early genetic events in HPV immortalised keratinocytes. Genes Chromosomes Cancer 31: 72-79. J.M. Davidson, K.L. GorringeL, S.F. Chin, B. Orsetti, C. Besret, C. Courtay-Cahen, I. Roberts, C. Theillet, C. Caldas, P.A. Edwards (2000) Molecular cytogenetic analysis of breast cancer cell lines. Br J Cancer 83: 1309-1317. R.R. De Krijger, C.M Mooy, J.O. Van Hemel, E.J. Sulkers, J.M. Kros, M.M. Bartelings, L.C. Govaerts (1999) CHARGE association-related ocular pathology in a newborn with partial trisomy 19q and partial monosomy 21q, from a maternal translocation (19;21)(q13.1;q22.3). Pediatr Dev Pathol 2: 577-0581 T.R. Dennis, A.D. Stock (1999) A molecular cytogenetic study of chromosome 3 rearrangements in small cell lung cancer; consistent involvement of chromosome band 3q13.2. Cancer Genet. Cytogenet. 113: 134-140. S. Dhar, J.A. Squire, M.P. Hande, R.J. Wellinger, T.K. Pandita (2000) Inactivation of 14-3-3 Influences Telomere Behavior and Ionizing Radiation-Induced Chromosomal Instability. Mol. Cell. Biol. 20: 7764-7772. J.A. Douglas, M. Boehnke, E. Gillanders, J.M. Trent, S.B. Gruber (2001) Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies. Nature Genetics 28: 361-364. B. Elenbaas, L. Spirio, F. Koerner, M.D. Fleming, D.B. Zimonjic, J.L. Donaher, N.C. Popescu, W.C. Hahn, R.A. Weinberg (2001). Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes & Dev. 15: 50-65. H. Elghezal, G. Le Guyader, I. Radford-Weiss, C. Perot, J. Van Den Akker, P. Eydoux, M. Vekemans, S.P. Romana (2001) Reassessment of childhood B-lineage lymphoblastic leukemia karyotypes using spectral analysis. Genes, Chromosomes and Cancer 30: 383-392. I. Fadl-Elmula, S. Kytola, Y. Pan, W.O. Lui, G. Derienzo, L. Forsberg, N. Mandahl, L. Gorunova, U.S. Bergerheim, S. Heim, C. Larsson (2001) Characterization of chromosomal abnormalities in uroepithelial carcinomas by G-banding, spectral karyotyping and FISH analysis. Int J Cancer 92: 824-831. FY. Fan, V.M. Siu (2001) Molecular cytogenetic characterization of a derivative chromosome 8 with an inverted duplication of 8p21.3-->p23.3 and a rearranged duplication of 8q24. Am J Med Genet. 102: 266-271. Y.S. Fan, V.M. Siu, J.H. Jung, J. Xu (2000) Sensitivity of multiple color spectral karyotyping in detecting small interchromosomal rearrangements. Genetic Testing 4: 9-14. E.W. Fleischman, S. Reshmi, O.I. Sokova, O.P. Kirichenko, L.N. Konstantinova, O.E. Kulagina, M.A. Frenkel, J.D. Rowley (1999) Increased karyotype precision using fluorescence in situ hybridization and spectral karyotyping in patients with myeloid malignancies. Cancer Genet. Cytogenet. 108: 166-70. Y. Garini, A. Gil, I. Bar-Am, D. Cabib, N. Katzir (1999) Signal to noise analysis of multiple color fluorescence imaging microscopy. Cytometry 35: 214-220. B.M. Ghadimi, D.L. Sackett, M.J. Difilippantonio, E. Schröck, T. Neumann, A. Jauho, G. Auer, T. Ried (2000) Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer 27: 183-190. B.M. Ghadimi, E. Schröck, R.L. Walker, D. Wangsa, A. Jauho, P.S. Meltzer, T. Ried (1999) Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas. Am. J. Pathol. 154: 525-36. D. Gisselsson, L. Pettersson, M. Höglund, M. Heidenblad, L. Gorunova, J. Wiegant, F. Mertens, P.D. Cin, F. Mitelman, N. Mandahl (2000) Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity Proc. Natl. Acad. Sci. USA 97: 5357-5362. S.G. Gray, S. Kytola, W.O. Lui, C. Larsson, T.J. Ekstrom (2000) Modulating IGFBP-3 expression by trichostatin A: potential therapeutic role in the treatment of hepatocellular carcinoma. Int. J. Mol. Med. 5: 33-41. C.A. Griffin, A.L. Hawkins, C. Dvorak, C. Henkle, T. Ellingham, E.J. Perlman (1999) Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. Cancer Res. 59: 2776-2780. B.R. Haddad, E. Schröck, J. Meck, J. Cowen, H. Young, M.A. Ferguson-Smith, S. du Manoir, T. Ried (1998) Identification of de novo chromosomal markers and derivatives by spectral karyotyping (SKY). Hum. Genet. 103: 619-25. Hilgenfeld E, Padilla-Nash H, McNeil N, Knutsen T, Montagna C, Tchinda J, Horst J, Ludwig WD, Serve H, Buchner T, Berdel WE, Schrock E, Ried T. (2001) Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2. Br J Haematol. 113: 305-317. E. Hilgenfeld, H. Padilla-Nash, E. Schröck, T. Ried (1999) Analysis of B-cell neoplasias by spectral karyotyping. Curr. Top. Microbiol. Immunol. 246: 169-174. B. Huang, Y. Ning, A.N. Lamb, C.J. Sandlin, M. Jamehdor, T. Ried, J. Bartley (1998) Identification of an unusual marker chromosome by spectral karyotyping. Am. J. Med. Genet. 80: 368-372. K. Inokuchi, H. Hamaguchi, M. Taniwaki, H. Yamaguchi, S. Tanosaki, K. Dan (2001) Establishment of a cell line with AML1-MTG8, TP53, and TP73 abnormalities from acute myelogenous leukemia. Genes, Chromosomes and Cancer 32: 182-187. Ishida F, Ueno M, Tanaka H, Makishima H, Suzawa K, Hosaka S, Hidaka E, Ishikawa M, Yamauchi K, Kitano K, Kiyosawa K. (2002) t(8;21;14)(q22;q22;q24) is a novel variant of t(8;21) with chimeric transcripts of AML1-ETO in acute myelogenous leukemia. Cancer Genet Cytogenet. 132: 133-135. J.D. Jiang, Y. Wang, C.A. Janish, J.F. Holland, J.G. Bekesi (1998) 3-Bromoacetylamino benzoylurea (3-BAABU), a new antimicrotubule cancericidal agent applied in cytogenetic analysis in hematology. Biomed. Pharmacother. 52: 270-81. D. Jones, M. Amin, N.G. Ordonez, A.B. Glassman, Hayes KJ, L.J. Medeiros (2001) Reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features. Mod Pathol. 14: 1059-67. S. Joyama, T. Ueda, K. Shimizu, I. Kudawara, M. Mano, H. Funai, K. Takemura, H. Yoshikawa (1999) Chromosome rearrangement at 17q25 and Xp11.2 in alveolar soft-part sarcoma: A case report and review of the literature. Cancer 86: 1246-1250. Jyoko N, Kuroda J, Kimura S, Kobayashi Y, Yoshikawa T. (2002) Comprehensive cytogenetic study by spectral karyotyping on blastic natural killer cell leukemia/lymphoma. Am J Hematol. 69: 234-235. N. Kakazu, E. Ashihara, S. Hada,T. Ueda, H. Sasaki, M. Terada, T. Abe See (2001) Development of spectral colour banding in cytogenetic analysis. Lancet 357: 529-530. N. Kakazu, K. Kito, T. Hitomi, J. Oita, K. Nishida, K. Masuda, T. Miki, T. Abe (2000) Characterization of complex chromosomal abnormalities in B-cell lymphoma by a combined spectral karyotyping (SKY) analysis and fluorescence in situ hybridization (FISH) using a 14q telomere probe. Am J Hematol. 65: 291-297. N. Kakazu, M. Taniwaki, S. Horiike, K. Nishida, T. Tatekawa, M. Nagai, T. Takahashi, T. Akaogi, J. Inazawa, M. Ohki, T. Abe (1999) Combined spectral karyotyping and DAPI banding analysis of chromosome abnormalities in myelodysplastic syndrome. Genes Chromosomes Cancer 26: 336-345. N. Kakazu, T. Abe (1998) Cytogenetic analysis of chromosome abnormalities in human cancer using SKY. Experimental Medicine (Jikken Igaku) 16: 1638-1641. H. Kanayama, W.O. Lui, M. Takahashi, T. Naroda, D. Kedra, F.K. Wong, Y. Kuroki, Y. Nakahori, C. Larsson, S. Kagawa, B.T. Teh (2001) Association of a novel constitutional translocation t(1q;3q) with familial renal cell carcinoma. J Med Genet.38: 165-170. G.B. Kerndrup, E. Kjeldsen (2001) Acute leukemia cytogenetics. an evaluation of combining G-band karyotyping with multi-color spectral karyotyping. Cancer Genet Cytogenet. 124: 7-11. Kimura S, Kakazu N, Kuroda J, Akaogi T, Hayashi H, Nishida K, Abe T. (2001) Agranular CD4+CD56+ blastic natural killer leukemia/lymphoma. Ann Hematol. 80: 228-231. T. Knutsen, V.K. Rao, T. Ried, L. Mickley, E. Schneider, K. Miyake, B.M. Ghadimi, H. Padilla-Nash, S. Pack, L. Greenberger, K. Cowan, M. Dean, T. Fojo, S. Bates (2000) Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines. Genes Chromosomes Cancer 27: 110-116. N. Komae, Y. Hibino, N. Sugano (1999) Analysis of micronuclei induced under hyperthermic conditions in human lymphocyte culture by fluorescence in situ hybridization (FISH) and spectral karyotyping (SKY) methods. Yakugaku Zasshi 119: 763-772. Krex D, Mohr B, Hauses M, Ehninger G, Schackert HK, Schackert G. (2001) Identification of uncommon chromosomal aberrations in the neuroglioma cell line H4 by spectral karyotyping. J Neurooncol. 52: 119-128. H. Kubota, T, Nishizaki, K, Harada, K, Harada, A, Oga, H. Ito, M. Suzuki, K. Sasaki (2001) Identification of recurrent chromosomal rearrangements and the unique relationship between low-level amplification and translocation in glioblastoma. Genes, Chromosomes and Cancer 31: 125-133. J. Kuroda, S. Kimura, T. Akaogi, H. Hayashi, K. Nishida, N. Kakazu, T. Abe (2000) Aggressive natural killer cell leukemia/lymphoma: a comprehensive cytogenetic study by spectral karyotyping. Ann. Hematol. 79: 519-522. S. Kytölä, J. Rummukainen, A. Nordgren, R. Karhu, F. Farnebo, J. Isola, C. Larsson (2000) Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping. Genes, Chromosomes and Cancer 28: 308-317. N.T. Leach, C. Jackson-Cook (2001) The application of spectral karyotyping (SKY) and fluorescent in situ hybridization (FISH) technology to determine the chromosomal content(s) of micronuclei. Mutat Res. 495: 11-19. D. Lev, O. Nakar, I. Bar-Am,A. Zudik, N. Watemberg, S. Finkelstien, N. Katzin, T. Lerman-Sagie (2000) CHARGE association in a child with de novo chromosomal aberration 46,X,der(X)t(X;2)(p22.1;q33) detected by spectral karyotyping. J Med Genet. 37: E47. D. Lev, M. Yanoov, S. Weintraub, T. Lerman-Sagie (2000) Progressive neurological deterioration in a child with distal arthrogryposis and whistling face. J Med Genet 37: 231-233. J. Liang, Y. Ning, R.-Y. Wang, H.M. Padilla-Nash, E. Schröck, D. Soenksen, L. Nagarajan, T. Ried (1999) Spectral karyotypic study of the HL-60 cell line: detection of complex rearrangements involving chromosomes 5, 7, and 16 and delineation of critical region of deletion on 5q31.1. Cancer Genet. Cytogenet. 113: 105-109. W.-O. Lui, J. Wejde, E. Tani, O. Brosjö, S. Kytölä, C. Larsson (2001) A highly aggressive primitive mesenchymal tumor with a translocation (1;19)(q12;q13.2), Cancer Genetics and Cytogenetics 127: 128-133. W.-O. Lui, S. Kytölä, L. Ånfalk, C. Larsson, L.-O. Farnebo (2000) Balanced translocation (3;7)(p25;q34): Another mechanism of tumorigenesis in follicular thyroid carcinoma? Cancer Genet Cytogenet. 119:109112. C. Luk, M. Tsao, J. Bayani, F. Shepherd, J.A. Squire (2001) Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization. Cancer Genet Cytogenet. 125: 87-99. R.A.F. MacLeod, W.G. Dirks, H.G. Drexler (2001) Persistent use of misidentified cell lines and its prevention. Genes, Chromosomes and Cancer 33: 103-104. R.A. MacLeod, D. Spitzer, I. Bar-Am, J.E. Sylvester, M. Kaufmann, A. Wernich, H.G. Drexler (2000) Karyotypic dissection of Hodgkin's disease cell lines reveals ectopic subtelomeres and ribosomal DNA at sites of multiple jumping translocations and genomic amplification. Leukemia 14: 1803-1814. M. Macville, E. Schröck, H. Padilla-Nash, C. Keck, B.M. Ghadini, D. Zimonjic, N. Popescu, T. Ried (1999) Comprehensive and definitive molecular cytogenetic characterization of HeLa cells by spectral karyotyping. Cancer Res. 59: 141-150. H.F. Mark, Y. Gray, Y. Mark, J. Khorsand, W. Sikov (1999) A multimodal approach in the diagnosis of patients with hematopoietic disorders. Cancer Genet. Cytogenet. 109: 14-20. J.A. Macoska, B. Beheshti, J.S. Rhim , B. Hukku, J. Lehr, K.J. Pienta, and J.A. Squire (2000) Genetic characterization of immortalized human prostate epithelial cell cultures: evidence for structural rearrangements of chromosome 8 and i(8q) chromosome formation in malignant-derived cells. Cytogenet. Cell Genet. 120: 50-57. V.D. Markovic, D. Bouman, J. Bayani, J. Al-Maghrabi, S. Kamel-Reid & J.A. Squire (2000) Lack of BCR/ABL reciprocal fusion in variant Philadelphia chromosome translocations: a use of double fusion signal FISH and spectral karyotyping. Leukemia 14: 1157-1160. C. Marquez, J. Cohen, S. Munne (1998) Chromosome identification in human oocytes and polar bodies by spectral karyotyping. Cytogenet. Cell Genet. 81: 254-258. S. Mathew, P.H. Rao, J. Dalton, J.R. Downing, S.C. Raimondi (2001) Multicolor spectral karyotyping identifies novel translocations in childhood acute lymphoblastic leukemia. Leukemia 15: 468-472. A Mégarbané, M.L. Lorc'h, H. Elghezal, G. Joly, P. Gosset, N. Souraty, L. Samaras, M. Prieur, M. Vekemans, C. Turleau, S.P. Romana (2001) Pure partial 7p trisomy including the TWIST, HOXA, and GLI3 genes. J Med Genet 38: 178-182. Mehra S, Messner H, Minden M, Chaganti RS. (2002) Molecular cytogenetic characterization of non-Hodgkin lymphoma cell lines. Genes Chromosomes Cancer 33: 225-234. R. Melcher, R. von Golitschek, C. Steinlein, D. Schindler, H. Neitzel, K. Kainer, M. Schmid, H. Hoehn (2000) Spectral karyotyping of Werner syndrome fibroblast cultures. Cytogenet Cell Genet. 91: 180-185. R. Melcher, C. Steinlein, W. Feichtinger, C.R. Müller, T. Menzel, H. Lührs, W. Scheppach, M. Schmid (2000) Spectral karyotyping of the human colon cancer cell lines SW480 and SW620. Cytogenet. Cell Genet. 88: 145-152. Mohr B, Bornhauser M, Platzbecker U, Freiberg-Richter J, Naumann R, Prange-Krex G, Mohm J, Kroschinsky F, Ehninger G, Thiede C. (2001) Problems with interphase fluorescence in situ hybridization in detecting BCR/ABL-positive cells in some patients using a novel technique with extra signals. Cancer Genet Cytogenet. 127: 111-117. B Mohr, M Bornhäuser, C Thiede, U Schäkel, M Schaich, T Illmer, U Pascheberg & G Ehninger (2000) Comparison of spectral karyotyping and conventional cytogenetics in 39 patients with acute myeloid leukemia and myelodysplastic syndrome. Leukemia 14: 1031-1038. S.H. Morelli, D.A. Deubler, L.J. Brothman, J.C. Carey, A.R. Brothman (1999) Partial trisomy 17p detected by spectral karyotyping. Clin Genet 55: 372-5. K. Mrózek, M. Iliszko, J. Ry , M. Babi ska, A. Niezabitowski, C.D. Bloomfield, J. Limon (2001) Spectral karyotyping reveals 17;22 fusions in a cytogenetically atypical dermatofibrosarcoma protuberans with a large marker chromosome as a sole abnormality. Genes, Chromosomes and Cancer 31: 182-186. Nanjangud G, Rao PH, Hegde A, Teruya-Feldstein J, Donnelly G, Qin J, Jhanwar SC, Zelenetz AD, Chaganti RS. (2002) Spectral karyotyping identifies new rearrangements, translocations, and clinical associations in diffuse large B-cell lymphoma. Blood 99: 2554-2561. N.C. Naus, E. van Drunen, A. de Klein, G.P.M. Luyten, D.A. Paridaens, J.C. Alers, B.R. Ksander, H.B. Beverloo, R.M. Slater (2001) Characterization of complex chromosomal abnormalities in uveal melanoma by fluorescence in situ hybridization, spectral karyotyping, and comparative genomic hybridization. Genes, Chromosomes and Cancer 30: 267-273. M.H. Ng, N. Wong, K.S. Tsang, S.H. Cheng, Y.F. Chung, K.W. Lo (2001) Recurrent chromosomal rearrangements involving breakpoints 3p21 and 19q13 in Chinese IgD multiple myeloma detected by G-banding and multicolor spectral karyotyping: A review of IgD karyotype literature. Hum Pathol. 32: 1016-1020. Y. Ning, C.H. Laundon, E. Schröck, P. Buchanan, T. Ried (1999) Prenatal diagnosis of a mosaic extra structurally abnormal chromosome by spectral karyotyping. Prenat. Diagn. 19: 480-482. Y. Ning, L. Nagarajan, E. Schröck, T. Ried (1998) Characterization of chromosome 5q deletions by subtelomeric probes and spectral karyotyping. Cancer Genet. Cytogenet. 103: 170-172. A. Nordgren, J. Schoumans, S. Soderhall, M. Nordenskjold, E. Blennow (2001) Interphase fluorescence in situ hybridization and spectral karyotyping reveals hidden genetic aberrations in children with acute lymphoblastic leukaemia and a normal banded karyotype. Br J Haematol. 114: 786-793. 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